FOXO4-DRI
experimentalA senolytic peptide that selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 interaction.
Overview
FOXO4-DRI is a D-retro-inverso peptide designed to interfere with the FOXO4-p53 protein interaction that keeps senescent ("zombie") cells alive. Developed by Dr. Peter de Keizer at Erasmus University Medical Center in the Netherlands, it was published in Cell in 2017.
Senescent cells accumulate with age and secrete inflammatory factors (SASP) that damage surrounding tissue and accelerate aging. FOXO4-DRI works by competitively binding to p53, preventing FOXO4 from sequestering it in the nucleus, thereby triggering selective apoptosis of senescent cells while leaving healthy cells unaffected. In aged mice, it restored fitness, fur density, and kidney function.
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Review FOXO4-DRI product information and ordering options from Ascension Peptides.
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Benefits
- ✓Selectively eliminates senescent cells
- ✓Reduces inflammatory SASP factors
- ✓Restored physical fitness in aged mice
- ✓Improved kidney function in animal models
- ✓Targets aging at a fundamental cellular level
- ✓Spares healthy non-senescent cells
Side Effects
- ⚠No human clinical data available
- ⚠Theoretical risk of excessive cell death
- ⚠Potential immune system effects
- ⚠Very expensive to synthesize
- ⚠Unknown long-term consequences of senescent cell clearance
- ⚠Experimental — no established safety profile
Where to Source FOXO4-DRI
Quality and purity matter with peptides. Only buy from suppliers that provide third-party Certificate of Analysis (COA) testing. Compare verified sources below:
Ascension Peptides
Third-party tested, US-based peptide supplier with COAs on every batch.
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Quick Comparison Guide
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⚠ Research Disclaimer: This information is for educational purposes only and is not medical advice. Consult a qualified healthcare professional before using FOXO4-DRI or any peptide. See our full medical disclaimer.
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