SS-31
clinical-trialsA mitochondria-targeted tetrapeptide that restores cellular energy production and protects against age-related mitochondrial dysfunction.
Overview
SS-31 (Elamipretide) is a synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) that selectively targets and concentrates in the inner mitochondrial membrane. Developed by Dr. Hazel Szeto and Dr. Peter Bhatt at Cornell, it binds to cardiolipin, a phospholipid essential for mitochondrial electron transport chain function.
By stabilizing cardiolipin interactions with cytochrome c, SS-31 optimizes electron transport, reduces reactive oxygen species (ROS) production, and restores ATP synthesis. It has been studied in clinical trials for Barth syndrome, heart failure, age-related macular degeneration, and primary mitochondrial myopathy. It represents one of the most advanced mitochondria-targeted therapeutics in development.
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Benefits
- ✓Restores mitochondrial ATP production
- ✓Reduces oxidative stress at the source
- ✓Protects against age-related mitochondrial decline
- ✓Improves cardiac function
- ✓May preserve kidney function
- ✓Clinically tested in multiple conditions
Side Effects
- ⚠Injection site reactions
- ⚠Headache
- ⚠Nausea
- ⚠Generally well-tolerated in clinical trials
- ⚠Some trials showed mixed efficacy results
- ⚠Long-term safety profile still being established
Where to Source SS-31
Quality and purity matter with peptides. Only buy from suppliers that provide third-party Certificate of Analysis (COA) testing. Compare verified sources below:
Ascension Peptides
Third-party tested, US-based peptide supplier with COAs on every batch.
Quick Comparison Guide
🔍 Buying Tips for SS-31
- • Always request Certificate of Analysis (COA) before purchasing
- • Verify the supplier's testing methodology and third-party lab credentials
- • Look for proper cold storage and shipping practices
- • Start with smaller quantities to test supplier quality
- • Join peptide communities for supplier reviews and experiences
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⚠ Research Disclaimer: This information is for educational purposes only and is not medical advice. Consult a qualified healthcare professional before using SS-31 or any peptide. See our full medical disclaimer.
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