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TB-500

moderate
Thymosin Beta-4TB4

A synthetic fraction of thymosin beta-4 that promotes tissue repair, reduces inflammation, and supports recovery from injuries.

Category
recovery
Dosage
2-5 mg twice weekly (loading), then 2 mg weekly (maintenance)
Half-Life
Estimated 14 days
Administration
Subcutaneous or intramuscular injection

Overview

TB-500 is a synthetic version of the naturally occurring peptide thymosin beta-4. It plays a crucial role in tissue repair and regeneration by promoting cell migration, blood vessel formation, and reducing inflammation. Originally studied in veterinary medicine (particularly racehorses), it has gained significant popularity in human biohacking communities.

TB-500 is often stacked with BPC-157 for synergistic healing effects. While direct human clinical trial data is limited, the peptide has a strong mechanistic basis and extensive animal research supporting its regenerative properties.

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Benefits

  • ✓Promotes tissue regeneration
  • ✓Reduces inflammation
  • ✓Improves flexibility and mobility
  • ✓Supports cardiac tissue repair
  • ✓Promotes hair regrowth (anecdotal)
  • ✓Synergistic with BPC-157

Side Effects

  • ⚠Generally well-tolerated
  • ⚠Temporary headache
  • ⚠Injection site irritation
  • ⚠Fatigue in initial doses
  • ⚠Theoretical concern about tumor growth (unproven)

Research Guides

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Buyer's Guide

Where to Buy TB-500: Trusted Vendor Guide for 2026

Find out where to buy TB-500 online for research. Compare TB-500 vendors, pricing, purity standards, and quality tips from trusted peptide sources in 2026.

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Dosage Guide

TB-500 Dosage Guide

Comprehensive TB-500 dosage guide with recommended doses for loading and maintenance phases. Learn reconstitution, injection technique, and cycling protocols.

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Where to Source TB-500

Quality and purity matter with peptides. Only buy from suppliers that provide third-party Certificate of Analysis (COA) testing. Compare verified sources below:

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Quick Comparison Guide

Quality
COA + 3rd party testing required
Purity
≥95% minimum standard
Storage
Lyophilized powder preferred
Shipping
Cold chain when needed

🔍 Buying Tips for TB-500

  • • Always request Certificate of Analysis (COA) before purchasing
  • • Verify the supplier's testing methodology and third-party lab credentials
  • • Look for proper cold storage and shipping practices
  • • Start with smaller quantities to test supplier quality
  • • Join peptide communities for supplier reviews and experiences

Disclosure: DailyVial may earn a commission from qualifying purchases. This doesn't affect our editorial recommendations. See our affiliate disclosure for details.

Frequently Asked Questions

What is TB-500 used for?
TB-500 (Thymosin Beta-4) is used for tissue repair and healing acceleration. Research shows it may help with muscle, tendon, ligament, and cardiovascular tissue recovery. It promotes cell migration, angiogenesis, and reduces inflammation.
How does TB-500 differ from BPC-157?
While both are healing peptides, TB-500 is better for systemic healing and larger muscle injuries, while BPC-157 excels at localized injury repair. TB-500 has a longer half-life (7-10 days) versus BPC-157 (4-6 hours), requiring less frequent dosing.
What is the typical TB-500 dosage?
Research dosages typically range from 2-5 mg per week, divided into 2-3 injections. A common protocol is 2.5 mg twice weekly for 4-6 weeks, followed by a maintenance dose of 2.5 mg weekly.
How long does TB-500 take to show results?
Initial effects may be noticed within 1-2 weeks, but significant healing improvements typically occur after 4-8 weeks of consistent use. The longer half-life means effects build up over time.
Is TB-500 safe for research?
TB-500 appears well-tolerated in animal studies with minimal side effects reported. However, it is not approved for human use and long-term safety data in humans is limited. It should only be used for research purposes.
Is TB-500 the same as Thymosin Beta-4?
TB-500 is a synthetic version of the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid protein found in all human and animal cells. TB-500 specifically replicates the portion of Thymosin Beta-4 responsible for its healing and tissue repair properties, making it more practical for research applications.
Is TB-500 banned in sports?
Yes, TB-500 (Thymosin Beta-4) is prohibited by WADA (World Anti-Doping Agency) and USADA under the S0 category of non-approved substances. It has been at the center of several high-profile doping cases in horse racing and professional sports. Athletes subject to drug testing should not use TB-500.
Can TB-500 help with hair growth?
Research suggests TB-500 may promote hair growth. Thymosin Beta-4 has been shown to stimulate hair follicle stem cells and promote the migration of hair follicle progenitor cells. Animal studies demonstrated increased hair growth in treated subjects. However, human clinical data specifically for hair regrowth is limited.
Where do you inject TB-500?
TB-500 is typically administered via subcutaneous injection in the abdominal area or near the injury site. Unlike BPC-157 which benefits from localized injection, TB-500 works systemically and does not need to be injected directly at the injury. Common injection sites include the lower abdomen, thigh, or upper arm fat pads.
How long does TB-500 stay in your system?
TB-500 has a relatively long half-life estimated at around 14 days, which is unusually long for a peptide. This means it remains active in the body for an extended period, allowing for less frequent dosing compared to other peptides. Most protocols use twice-weekly injections during loading phases and once-weekly for maintenance. For drug testing purposes, TB-500 metabolites may be detectable for several weeks after last use.
Does TB-500 promote cancer growth?
This is a common concern due to TB-500's role in promoting angiogenesis (new blood vessel formation) and cell migration. Some researchers have raised theoretical concerns that these properties could support tumor growth. However, other studies suggest Thymosin Beta-4 may actually have anti-tumor properties in certain contexts. The evidence is mixed and insufficient to draw definitive conclusions. Individuals with active cancer or a history of cancer should exercise caution and consult their healthcare provider.
Can TB-500 help with heart repair?
Animal studies show promising results for TB-500 in cardiac repair. Research in mice demonstrated that Thymosin Beta-4 can activate cardiac progenitor cells and promote heart muscle regeneration after injury. Studies have shown improved cardiac function following myocardial infarction in animal models. A human clinical trial (ASTRA) investigated Thymosin Beta-4 for acute myocardial infarction but results were modest. More research is needed.
What is the loading phase for TB-500?
A typical TB-500 loading phase involves higher initial doses for the first 4-6 weeks to build up systemic levels, followed by a lower maintenance dose. Common loading protocols use 2-2.5mg twice weekly (4-5mg total per week) for 4-6 weeks, then reduce to 2-2.5mg once weekly for maintenance. The loading phase is believed to saturate tissues and accelerate initial healing before transitioning to a sustaining dose.
How do you reconstitute TB-500?
To reconstitute TB-500, add bacteriostatic water to the lyophilized (freeze-dried) powder vial. A common method is to add 1-2 mL of bacteriostatic water by slowly injecting it down the side of the vial — do not squirt directly onto the powder. Gently swirl the vial until fully dissolved (do not shake vigorously). Once reconstituted, store in the refrigerator and use within 3-4 weeks.
Can TB-500 help with joint pain?
Research suggests TB-500 may help with joint pain through its anti-inflammatory properties and ability to promote tissue repair. Animal studies show it can reduce inflammation in joints and support cartilage repair. Many anecdotal reports from users describe significant improvements in joint mobility and reduced pain, particularly when stacked with BPC-157. However, controlled human clinical trials are lacking.
Does TB-500 need to be injected near the injury?
Unlike BPC-157, TB-500 does not need to be injected near the injury site. TB-500 is a systemic peptide with a longer half-life (approximately 14 days), meaning it travels throughout the body after injection. Subcutaneous injection in the abdomen or thigh is the most common method. The peptide will reach the injury site through normal circulation and accumulate where inflammation and damage signals are present.
What is the difference between TB-500 and Thymosin Alpha-1?
TB-500 (Thymosin Beta-4) and Thymosin Alpha-1 (Ta1) are both thymus-derived peptides but have very different functions. TB-500 primarily promotes tissue repair, wound healing, and reduces inflammation. Thymosin Alpha-1 is an immune modulator that enhances T-cell function and is used for immune support, chronic infections, and as a vaccine adjuvant. Ta1 is actually FDA-approved in some countries (as Zadaxin) for hepatitis B treatment.
Can TB-500 be taken orally?
TB-500 is not typically effective when taken orally. Unlike BPC-157, which has unusual gastric acid stability, TB-500 is degraded by digestive enzymes before it can be absorbed into the bloodstream. Subcutaneous or intramuscular injection is the standard route of administration for TB-500. Some companies offer oral or sublingual formulations, but their bioavailability is questionable and not supported by research.

⚠ Research Disclaimer: This information is for educational purposes only and is not medical advice. Consult a qualified healthcare professional before using TB-500 or any peptide. See our full medical disclaimer.

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Research Guides

In-depth resources to help you source and use TB-500 effectively in research.

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